Imuran 50 Mg

Imuran 50 Mg

Price range: $19.00 through $54.00

Imuran 50 Mg provides 50 mg azathioprine, an antimetabolite immunosuppressant essential for preventing acute kidney transplant rejection and managing refractory rheumatoid arthritis. It inhibits purine synthesis to dampen hyperactive immune function, with dosing optimized through therapeutic drug monitoring to balance efficacy and toxicity risks.

USA Brand Name Imuran
Strength 50mg
Generic Name Azathioprine

Imuran 50 Mg

Variant Price Units Quantity Add to Cart
25 Tablet/s $19.00 $0.76
50 Tablet/s $36.96 $0.74
75 Tablet/s $54.00 $0.72

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Medically Reviewed By
Dr. Emily Carter

Dr. Emily Carter

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📋 Product Description

Generic Ingredient

Azathioprine.

Corresponding USA Brand Names

Imuran.

Product Description and Use

Imuran 50 Mg contains azathioprine, an immunosuppressive agent used to prevent organ rejection and treat autoimmune conditions. It is indicated for preventing kidney transplant rejection and managing severe rheumatoid arthritis unresponsive to other therapies. For information on rheumatoid arthritis treatment options, refer to the Mayo Clinic overview of rheumatoid arthritis.

Manufacturing Details

Imuran 50 Mg is originally manufactured by Prometheus Laboratories Inc. Generic equivalents are produced by various FDA-approved US pharmaceutical companies, including Mylan and Teva, in compliance with United States Pharmacopeia standards.

Potency and Formulation

Imuran 50 Mg contains 50 mg azathioprine per tablet. Available in bottles of 100 tablets.

Form of Medication

Oral tablet.

Primary Medical Indications

  • Prevention of renal allograft rejection in kidney transplant recipients.
  • Treatment of severe, active rheumatoid arthritis in patients who have not responded adequately to methotrexate or other disease-modifying antirheumatic drugs.

Mechanism of Action

Azathioprine in Imuran 50 Mg is metabolized to 6-mercaptopurine, which is incorporated into DNA and RNA, inhibiting purine synthesis and suppressing cell-mediated immune responses. This reduces T-cell proliferation and antibody production, mitigating transplant rejection and autoimmune inflammation. For a detailed review of its immunosuppressive pharmacology, see the NCBI StatPearls entry on azathioprine.

Essential Pre-Use Checklist

  • Obtain baseline complete blood count, liver function tests, and TPMT enzyme activity assessment.
  • Confirm no active infections or hypersensitivity to azathioprine or mercaptopurine.
  • Review vaccination status, avoiding live vaccines during therapy.
  • Verify pregnancy status and contraceptive use.
  • Ensure monitoring plan for hematologic parameters is established.

Specific Contraindications for Use

  • Hypersensitivity to azathioprine or its metabolites.
  • Prior use of alkylating agents in combination therapy.
  • Active untreated infections.
  • Pregnancy or lactation without risk-benefit assessment.

Information to Disclose to Your Healthcare Provider

  • History of malignancies or prior chemotherapy.
  • Current infections or recent vaccinations.
  • All concurrent medications, including allopurinol or warfarin.
  • Family or personal history of TPMT deficiency.
  • Any bleeding disorders or gastrointestinal issues.

Dosage and Administration

Dosage of Imuran 50 Mg is individualized based on condition and body weight. For kidney transplant, the initial dose is 3-5 mg/kg/day orally, adjusted to maintain white blood cell count above 3000/mm³. For rheumatoid arthritis, start at 1 mg/kg/day (up to 2.5 mg/kg/day), with methotrexate if needed. Administer once daily, preferably at the same time.

Correct Application Amount

Take Imuran 50 Mg tablets as prescribed, typically 1-3 tablets daily based on weight and response. Do not exceed maximum dose without monitoring. Swallow whole with water.

Proper Application Method

  1. Wash hands before handling the tablet.
  2. Place the tablet on the tongue or directly into the mouth.
  3. Swallow with a full glass of water.
  4. Take with or without food, but consistently.
  5. Avoid splitting or crushing unless directed.

Recommended Treatment Duration

For kidney transplant prevention, lifelong maintenance therapy is common, with periodic dose adjustments. For rheumatoid arthritis, use indefinitely if benefits outweigh risks, with regular efficacy assessments every 3-6 months.

Procedures for Overdose

Seek emergency medical care immediately or contact poison control at 1-800-222-1222. Symptoms may include severe nausea, myelosuppression, or hepatic toxicity. Provide ingestion details; supportive care including blood transfusions may be required.

Guidance for a Missed Application

Take the missed dose of Imuran 50 Mg as soon as remembered if within 12 hours. Skip if nearer to the next dose; do not double up. Resume regular schedule. Notify the provider if multiple doses are missed.

Potential Adverse Reactions

  • Nausea or vomiting.
  • Leukopenia or thrombocytopenia.
  • Hepatotoxicity.
  • Increased infection risk.
  • Skin rash or alopecia.
  • Pancreatitis (rare).

Known Medication Interactions

Azathioprine levels increase with allopurinol (reduce dose by 75%); avoid combination without adjustment. Warfarin effects may potentiate, requiring INR monitoring. Ribavirin increases myelosuppression risk. Angiotensin-converting enzyme inhibitors may enhance hematologic toxicity.

Purchasing and Availability

Imuran 50 Mg and generic azathioprine tablets are available by prescription at US pharmacies such as CVS, Walgreens, and specialty transplant centers. For sourcing guidance and pricing comparisons, visit Pharmasworld.com.

Key Warnings and General Precautions

  • Risk of severe myelosuppression; monitor CBC weekly initially, then monthly.
  • Potential carcinogenicity with long-term use; screen for skin cancer and lymphoma.
  • Avoid live vaccines and limit sun exposure.
  • Hepatotoxicity risk; perform liver function tests regularly.
  • Increased infection susceptibility; report fever or signs of infection promptly.
  • Contraindicated in pregnancy due to teratogenic effects; use effective contraception.

Important Patient Reminders

  • Adhere to blood monitoring schedule without fail.
  • Report unusual fatigue, bruising, or infections immediately.
  • Maintain consistent dosing to sustain therapeutic levels.
  • Inform all providers of azathioprine use before new treatments.

Correct Storage Instructions

Store at controlled room temperature 20°C to 25°C (68°F to 77°F). Protect from light. Keep in a tight container. Discard expired product.
size25 Tablet/s, 50 Tablet/s, 75 Tablet/s
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